hofmann elimination pharmacology

(Reproduced, with permission of Elsevier, from Standaert FG. J Pharmacokinet Biopharm 1992; 17:601-14. The iodide then reacts with silver oxide to form silver iodide which is insoluble and precipitates out of solution and a silver oxide ion which deproto-nates water to form a hydroxide ion. Dixon WJ, Massey FJJ: Introduction to Statistical Analysis. Jie Cheng, Gaohong He, Fengxiang Zhang. [5]and Kent et al. (Matteo) Professor of Clinical Anesthesiology, Department of Anesthesiology, College of Physicians and Surgeons of Columbia University. Doo Sung Hwang, Tauqir A. Sherazi, Joon Yong Sohn, Yeong Chang Noh, Chi Hoon Park, Michael D. Guiver, Young Moo Lee. Note: [1]and Lien et al. Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Luiz K. C. de Souza, Juliana J. R. Pardauil, José R. Zamian, Geraldo N. da Rocha Filho, Carlos E. F. da Costa. Shi WZ, Fahey MR, Fisher DM, Miller RD: Modification of central nervous system effects of laudanosine by inhalational anaesthetics. The percent twitch suppression relative to baseline was also measured at the time of each blood sample. Mechanistic Study of the Gas-Phase In-Source Hofmann Elimination of Doubly Quaternized Cinchona-Alkaloid Based Phase-Transfer Catalysts by (+)-Electrospray Ionization/Tandem Mass Spectrometry. Mechanisms of elimination reactions—XXVI. eCollection 2018 Apr. Bi- and triexponential functions were fit to the plasma cisatracurium concentration versus time data by generalized least-squares regression, with the inverse square of the predicted concentration used as the iterative weighting function. Find more information about Crossref citation counts. Figure 2. Facile and green fabrication of polybenzoxazine-based composite anion-exchange membranes with a self-cross-linked structure. Eugene Ornstein, Cynthia A Lien, Richard S. Matteo, Noeleen D. Ostapkovich, Jaime Diaz, Karen B. Wolf; Pharmacodynamics and Pharmacokinetics of Cisatracurium in Geriatric Surgical Patients. This tendency, known as the Hofmann alkene synthesis rule, is in contrast to usual elimination reactions, where Zaitsev's rule … This is in direct contrast to normal elimination reactions where the more substituted, stable product is dominant (Zaitsev's rule). You’ve supercharged your research process with ACS and Mendeley! National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Synthesis of Trialkylamines with Extreme Steric Hindrance and Their Decay by a Hofmann-like Elimination Reaction. Drugs. There was a 17% increase in the volume of distribution in elderly patients; there was no difference in plasma clearance between elderly and younger patients. Please note: If you switch to a different device, you may be asked to login again with only your ACS ID. The clearance of cisatracurium due to Hofmann elimination and organ elimination was estimated by applying a nontraditional two-compartment pharmacokinetic model with elimination occurring from both compartments to plasma cisatracurium concentration-time data from 31 healthy adult surgical patients with normal renal and hepatic function. Wagner J: Linear pharmacokinetic equations allowing direct calculation of many needed pharmacokinetic parameters from the coefficients and exponents of polyexponential equations which have been fitted to the data. Atracurium, a nondepolarizing muscle relaxant, is eliminated through several pathways, including Hofmann elimination (spontaneous degradation in plasma and tissue at normal body pH and temperature) and ester hydrolysis (catalysis by nonspecific esterases). Of note, Hull has suggested that inasmuch as plasma concentration is the only basis for the model, the single output model used in this study, despite conceptual limitations, is equally valid as a model with an additional output from the peripheral compartment. Recovery to 25% of baseline was accelerated (33 min), with a recovery index (17 min) and elimination half-life (24.8 min) that was consistent with the other patients. 1986 Sep;65(3):286-91 Presented in part at the annual meeting of the American Society of Anesthesiologists, San Francisco, CA, October, 1994. Twelve elderly (aged 65-82 yr) and 12 younger patients (aged 30-49 yr) were anesthetized with nitrous oxide, fentanyl, and isoflurane (0.7%, end-tidal). The similar total clearances observed are consistent with the minor role played by renal elimination. Effective doses of cisatracurium in the adult and the elderly. A larger distribution volume in the elderly contributed to a small increase in elimination half-life. [10]. The possible role of conformational isomerism in the biological actions of acetylcholine. Get the latest research from NIH: https://www.nih.gov/coronavirus. These metrics are regularly updated to reflect usage leading up to the last few days. Br J Anaesth 1987; 59:211-7. This article is cited by One or More CC Bond(s) by Elimination of S, Se, Te, N, P, As, Sb, Bi, Si, Ge, B or Metal Functions. A review of its pharmacology and clinical potential in anaesthetic practice. 2018 Feb 23;31(2):177-179. doi: 10.1080/08998280.2017.1416237. [29]. [22–28]No clinical evidence of cerebral irritation or excitation attributable to atracurium was reported in these cases. Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. Written informed consent was obtained from 12 elderly (aged 65–82 yr) and 12 younger (aged 30–49 yr) adult patients scheduled for elective neurosurgical procedures.

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